Mie Kee Lam1,2, Taku Iwabuchi1,
Kensuke Saito1, Kagayaki Kuroda3,4
1School of Engineering, Tokai
University, Hiratsuka, Kanagawa, Japan; 2Image Sciences Institute,
University Medical Center Utrecht, Utrecht, Netherlands; 3Graduate
School of Engineering, Tokai University, Hiratsuka, Kanagawa, Japan; 4Medical
Device Development Center, Foundation for Biomedical Research and Innovation,
Kobe, Hyogo, Japan
Numerical
simulations were performed to investigate the effect of thermal shift of water
proton resonance on the accuracy of methylene T1 estimation for fat
temperature quantification with multiple flip angle, multipoint Dixon
acquisitions and a least square estimation scheme. The performance of
separating methylene and methyl, and estimating T1's of those species were
successful as far as the frequency separations between those species and
water was exact. The results with incomplete setting of the frequency
separations showed that the error in methylene T1 would be controlled and an
accuracy of 4C can be achieved by adjusting the separation within an error
of 0.05 ppm.