Andrew B. Holbrook1,2, Punit Prakash3,
Peter Jones3, Catherine Planey2, Juan M. Santos4,5,
Chris J. Diederich3, Kim Butts Pauly2, F. Graham Sommer2
1Bioengineering, Stanford University,
Stanford, CA, United States; 2Radiology, Stanford University,
Stanford, CA, United States; 3Radiation Oncology, UCSF, San
Francisco, CA, United States; 4HeartVista, Los Altos, CA, United
States; 5Electrical Engineering, Stanford University, Stanford,
CA, United States
Targeted
prostate ablation with transurethral multisectored ultrasound applicators
could be improved with an integrated imaging platform that minimizes
procedural setup and treatment time. The purpose of this work was to
integrate device localization, prostate-specific planning tools, and
multi-slice MR thermometry into a single imaging platform. Various phantom experiments were performed
to validate each of these steps.
Device localization and MR tracking was validated in a phantom, and an
ablation was performed in another phantom with multi-slice thermometry and
ROI feedback. The platform successfully
measured temperature rises and relayed that data to external power control
software that regulated the ablation.