Hassan Bagher-Ebadian1,2, Jayant Narang3,
James Russel Ewing1, Siamak Pourabdollah Nejad-Davarani1,4,
Mohammad Hossein Asgari1, Sona Saksena3, Rajan Jain3
1Neurology, Henry Ford Hospital,
Detroit, MI, United States; 2Physics, Oakland University,
Rochester, MI, United States; 3Radiology, Henry Ford Hospital,
Detroit, MI, United States; 4Biomedical Engineering, University of
Michigan, Ann Arbor, MI, United States
The
purpose of this study is comparison of Dynamic susceptibility contrast
enhanced MR perfusion (DSC-MRP) and CT Perfusion (CTP) in brain tumors
patients in normal as well as abnormal regions. CTP maps were calculated
using the Johnson and Wilson Model and DSC-MRP maps were calculated based on
conventional singular value decomposition (SVD) technique. The results imply
that there is underestimation of all perfusion parameters by SVD technique as
compared to CTP mostly due to the fact that DSC-MRP only measures CBV from
the microvasculature as well as due to the non-linearity of arterial input
function with Contrast Agent (CA) concentration.