Quantification of Cerebral Blood Flow, Oxygen Extraction Fraction, and Oxygen Metabolic Index in Human with Inhalation of Air and Carbogen

Hongyu An¹, Souvik Sen¹, Yasheng Chen¹, William Powers¹, Weili Lin¹

In this study, we have demonstrated that using CASL and ASE methods, CBF and OEF can be consistently measured in human under repeated air and carbogen inhalation. In agreement with previous PET study, an increase of CBF along with a reciprocal decrease of OEF, and an unchanged OMI were detected with carbogen inhalation.