Yufen Chen1, Jiongjiong Wang1,
Marc Korczykowski1, Maria Fernandez-Seara2, John A.
Detre1
1Center of Functional Neuroimaging,
University of Pennsylvania, Philadelphia, PA, United States; 2Center
for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain
Pseudo-continuous
arterial spin labeling is a recent addition to the family of ASL methods that
combines the high signal-to-noise ratio (SNR) of continuous methods and the
lower duty cycle of pulsed methods. To date, no formal within- and
across-session comparison between the methods has been performed. Here, we
compare the reproducibility of three variants of ASL: continuous, pulsed and
pseudo-continuous. Our results demonstrate that pCASL and PASL have the
lowest degree of variations (~13%) in scans repeated after one week, pCASL
also has higher temporal SNR, which makes it a favorable method for measuring
cerebral blood flow.