Ellen
Brunenberg1, Erik Pelgrim1, Bart ter Haar Romeny1,
Bram Platel2
1Biomedical Engineering, Eindhoven
University of Technology, Eindhoven, Netherlands; 2Biomedical
Engineering, Maastricht University Medical Center, Maastricht, Netherlands
Deep
Brain Stimulation of the STN for Parkinsons alleviates motor symptoms, but
often causes cognitive or emotional side effects. In this abstract, we
present the results of different clustering algorithms in order to separate
the rat STN motor and cognitive/emotional parts. We performed k-means and
graph cuts clustering on spherical harmonics coefficients for each voxel in
an atlas-based ROI around the STN. Graph cuts clustering results in a medial
STN cluster, which might correspond to the cognitive/emotional part of the
rat STN. Future research could focus on other HARDI distance measures and on
fiber tracking projections as clustering input.