Junzhong Xu1, Ha-Kyu Jeong1, Mark
D. Does1, Adam W. Anderson1, Li Min Chen1,
John C. Gore1
1Institute of Imaging Science,
Vanderbilt University, Nashville, TN, United States
The
FA dependence on diffusion time was studied using temporal diffusion
spectroscopy, which employs an oscillating gradient spin echo sequence and
has the ability to probe much shorter diffusion times. A clear dependence of
white matter factional anisotropy on effective diffusion time has been
observed in a fixed monkey brain. The results were also predicted by computer
simulations. The dependence observed in this study provides a means to probe
diffusion restriction and hindrance at sub-cellular length scales, e.g.
intracellular structures, and may provide insights into the microstructure of
biological tissues and clarify the origins of anisotropy diffusion in white
matter.