Yijing Wu1, Kevin M. Johnson1,
Steven R. Kecskemeti1, Charlse A. Mistretta2, Patrick
Alan Turski3
1Medical Physics, University of
Wisconsin, Madison, Madison, WI, United States; 2Medical Physics
and Radiologly, University of Wisconsin, Madison, Madison, WI, United States;
3Radiology, University of Wisconsin, Madison, Madison, WI, United
States
Time
resolved contrast-enhanced magnetic resonance angiography has been widely
used to evaluate vascular hemodynamics. Due to recent concern of the NSF
disease, eliminating or reducing Gadolinium-based contrast agent is
desirable. HYBRID HYPR decouples the high spatial resolution and SNR, which
require relative long scan time, from the high temporal resolution, which
demands for fast data acquisitions. It used the HYPR constrained
reconstruction to obtain high temporal resolution, high spatial resolution,
and high SNR image series. The hypothesis of this work is that the contrast
dose can be reduced using the HYBRID HYPR technique: the SNR of the HYPR
images is primarily determined by the composite, which is generated using
minimal mount of contrast agent (e.g. post contrast phase-contrast images) or
can be acquired before contrast injection (e.g. Time-of-Flight images). High
temporal and spatial resolution time resolved contrast-enhanced MRA can be
obtained by using Low Dose HYBRID HYPR method with contrast dose as low as
1ml.