Abstract #3741

A DNA-Targeted Gadolinium Chelate to Selectively Enhance Acutely Injured Myocardium

Shuning Huang¹, Hushan Yuan², Howard Chen³, Guangping Dai¹, Lee Josephson², David E. Sosnovik^1,3

¹Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; ²Center for Translation Nuclear and Molecular Imaging, Massachusetts General Hospital, Charlestown, MA, United States; ³Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA, United States

Delayed enhancement of gadolinium cannot discriminate acute and chronic injury since both produce similar changes in the pharmacokinetics of small gadolinium chelates, such as Gd-DTPA. Here, we demonstrated that the acute myocardial infarction can be distinguished from both subacute and chronic myocardial injury by utilizing a DNA-targeted gadolinium chelate (Gd-TO).