Stanislas Rapacchi1, Pierre Croisille,
1,2, Vinay Pai3, Denis Grenier1, Magalie Viallon4,
Peter Kellman3, Nathan Mewton, 1,2, Han Wen3
1CREATIS, Universit Lyon 1, INSA Lyon,
Villeurbanne, France; 2Hopital Cardiologique et Pneumologique L.
Pradel, Lyon, France, France; 3LCE/NHLBI/NIH, United States; 4Hopital
Cantonal Universitaire de Genve, Switzerland
Free
breathing in vivo cardiac Diffusion Weighted Imaging (DWI) is highly sensitive
to physiologic motion. To cope with this issue, we designed a DWI protocol
which repeats image acquisition multiple times with incremental trigger
delays to cover a large time window in diastole. After registration, a
localized Principal Component Analysis (PCA) is employed to reduce inter
images myocardium deformation, thus improving final image quality. Then
temporal Maximal Intensity Projection (tMIP) (3) is used to find the
diffusion weighted intensity for each pixel. We present the benefits of our method
and preliminary results in healthy and diseased volunteers.