Theory-Based Single-Point T1 Mapping for Quantitative Analysis of First-Pass Cardiac Perfusion MRI: A Validation Study

Elodie Breton¹, Daniel Kim¹, Sohae Chung¹, Leon Axel¹

Quantitative analysis of first-pass contrast-enhanced cardiac perfusion MRI requires the signal-time curve be converted to Gd-DTPA concentration-time curve. A theory-based single-point T₁ measurement method has been proposed and validated in phantoms at 1.5T. In this study at 3T, the sensitivity to B₁ variations and blood inflow of the single-point T₁ mapping method was first evaluated depending on its linear or centric k-space trajectory. Then, the centric k-space trajectory T₁ mapping pulse sequence was validated in vivo against a multi-point saturation recovery T₁ measurement method in the left ventricular myocardium and cavity.