Aleksandra Radjenovic1, John D. Biglands1,
Abdulghani Larghat1, John P. Ridgway1, Michael
Jerosch-Herold2, John P. Greenwood1, Sven Plein1
1School of Medicine, University of
Leeds, Leeds, England, United Kingdom; 2Brigham and Womens
Hospital, Harvard Medical School, Boston, MA, United States
Dynamic
contrast-enhanced MRI was performed in 17 volunteers to simultaneously assess
systolic and diastolic myocardial blood flow (MBF). At rest transmural MBF
estimates were similar in systole and diastole (1.6 0.42 vs 1.7 0.49
ml/g/min, p>0.05). During adenosine-induced hyperaemia, MBF was
significantly lower in systole than diastole (4.3 0.93 vs 5.7 1.7
ml/g/min, p < 0.0001). Subendocardial MBF was higher than subepicaridal
MBF, apart from systole at stress where this relation was reversed. In
conclusion, estimates of hyperaemic MBF differ significantly between systole
and diastole, following the expected physiological pattern of preferential
diastolic filling.