Kristine
Skrdal1, Natale Rolim1, Ole Christian Eidheim2,
Marius Widere1, Ulrik Wislff1, Pl Erik Goa3,
Marte Thuen1
1Department of Circulation and Medical
Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Department
of Laboratory Medicine, Children's and Women's Health, Norwegian University
of Science and Technology, Trondheim, Norway; 3Department of
Medical Imaging, St. Olavs University Hospital, Trondheim, Norway
Type
II diabetic patients suffer from higher susceptibility to develop post
myocardial infarction (MI) heart failure. By adapting a self-gated FLASH to a
murine model of the diabetic heart, we obtained multiple slices of the left
ventricle and assessed changes in cardiac physiology post MI. Diabetic MI
mice displayed decreased cardiac contractility and increased end-systolic
volume, while non-diabetic MI mice presented increased end-diastolic volume
with preserved ejection fraction. These data suggest that imaging of murine
hearts is achievable using a self-gated FLASH, and the results are accurate
enough to detect differences in functional analysis between genotypes and interventions.