Hsiao-Ying Wey1,2, Timothy Q. Duong1,2
1Research Imaging Institute, UT Health
Science Center at San Antonio, San Antonio, TX, United States; 2Radiology,
UT Health Science Center at San Antonio, San Antonio, TX, United States
Brains
of large non-human primates are highly evolved with extensive gyrations that
are most similar to humans compared to other species, resulting in better
recapitulation of many human diseases compared to the more commonly used
rodent models. This study compared the stimulus-evoked CMRO2
changes in baboons under isoflurane versus ketamine. Visual and somatosenory
stimulations were employed. BOLD and CBF were measured simultaneously using
the arterial-spin-labeling technique on a Siemens 3T TIM-Trio. Davis
biophysical BOLD model was used to calculate CMRO2 changes via
hypercapnic calibration. The comparisons of various physiological parameters
were made between isoflurane and ketmaine anesthetics.