Abstract #3523

Correlation of Changes in Brain Activation and Cognitive Impairment During 30 Hours of Continuous Sleep Deprivation Using Latent Growth Curve Analysis

Jason Glenn Parker¹, Eric Zalusky¹, J. Lynn Caldwell², Regina M. Schmidt², Laurie Quill³, Cemil Kirbas¹, Ke Cheng Liu⁴

¹Innovation Center, Kettering Health Network, Kettering, OH, United States; ²Human Effectiveness Directorate, Wright-Patterson AFB, Dayton, OH, United States; ³Research Institute, University of Dayton, Dayton, OH, United States; ⁴Siemens Medical Solutions, United States

Previous studies correlating changes in fMRI activation with sleep deprivation-induced cognitive impairment have assumed a linear increase in cognitive impairment over a period of sleep deprivation, but this method fails to model the nonlinear effects of circadian rhythm on cognition. In this work, we seek to use a latent growth curve analysis which models each individual subject's fatigue vulnerability profile using a 3rd order polynomial to correlate changes in brain activation and deactivation between rested wakefulness and 30 hours of sleep deprivation with cognitive impairment.