Gopikrishna Deshpande1, Priya Santhanam1,
Xiaoping Hu1
1Department of Biomedical Engineering,
Georgia Institute of Technology and Emory University, Atlanta, GA, United
States
Granger
causality, though not requiring a priori assumptions, is influenced by the
zero-lag correlation in resting state networks (RSNs) such as default mode
(DMN), hippocampal cortical memory (HCMN), dorsal attention (DAN) and
fronto-parietal control (FPCN) networks. We simultaneously derived functional
and effective connectivities in these RSNs using correlation-purged Granger
causality, a measure capable of reliably inferring causality without
interference from correlation. Our results show extensive causal interactions
between RSNs with the posterior cingulate and inferior parietal areas acting
as major transit hubs. In addition, our results also support the role of FPCN
in the control of DMN and DAN.