Christian Labadie1,2, Stefan Hetzer1,
Toralf Mildner1, Diana R. Amariei3, Monique Frcon4,
Harald E. Mller1,2
1Max Planck Institute for Human
Cognitive and Brain Sciences, Leipzig, Germany; 2Faculty of
Physics and Earth Science, University of Leipzig, Germany; 3Servei
de Ressonncia Magntica Nuclear, Universitat Autnoma de Barcelona, Spain; 4Laboratoire
de Spectromtrie Ionique et Molculaire, Universit Claude Bernard Lyon 1,
France
A
novel MRSI sequence, based on a double-shot echo planar spectroscopic
readout, offers a full k-space sampling despite the limitation imposed by the
spectral dwell-time of proton spectroscopy at 3 Tesla. In 61 sec, a
spectroscopic image was acquired with a 12 x 12 matrix, TE of 33 ms, voxels
of 4.91 mL and 16 steps EXOR phase cycling. The quantitation of the voxel spectra
significantly determined NAA, creatine, choline and myo-inositol. A longer
acquisition of 3 min 44 sec further permits to detect glutamine and
glutamate.