Changho Choi1, Ivan Dimitrov1,2,
Deborah Douglas1, Aditya Patel1
1Advanced Imaging Research Center,
University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Philips
Medical Systems, Cleveland, OH, United States
Measurement
of glycine (Gly) in the human brain by 1H-MRS at 7T is reported. A
point-resolved spectroscopy (PRESS) sequence with subecho times optimized for
differentiation between Gly and myo-inositol was applied for measuring the
metabolites in the prefrontal and left frontal cortices of a healthy adult
brain, which are gray and white matter dominant, respectively. The
Gly-to-creatine concentration ratios were observed to be approximately 2-fold
higher in prefrontal than in left frontal.
This result suggests that Gly may be present predominantly in gray
matter compared to white matter.