Albert P. Chen1, Charles H. Cunningham2,
James Tropp3, Kayvan Keshari4, Mark VanCriekinge4,
John Kurhanewicz4, Ralph E. Hurd5
1GE Healthcare, Toronto, ON, Canada; 2Imaging
Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3GE
Healthcare, Fremont, CA, United States; 4Radiology, UCSF, San
Francisco, CA, United States; 5GE Healthcare, Menlo Park, CA,
United States
The
ability to accurately measure or predict the polarization of hyperpolarized
13C metabolic imaging substrates at the time of the MR experiment is
necessary for quantitative kinetics data or metabolite concentrations. In this study, the feasibility of using asymmetry
of the pyruvate C2 resonance (from 1% natural abundance of [1,2-13C2]
pyruvate) to estimate the polarization of the [1-13C] pyruvate in
vivo is demonstrated.