Ashok Sharma1,
Uma Sharma2, N R. Jagannathan2, Moganty R. Rajeswari1
1Department of Biochemistry, All India
Institute of Medical Sciences, New Delhi, Delhi, India; 2Department
of NMR & MRI Facility, All India Institute of Medical Sciences, New
Delhi, Delhi, India
MR
relaxometry offers the potential for investigating the microstructural tissue
properties and the ability to detect early changes of water mobility resulting
from therapy-induced changes. In this study we report the cisplatin induced
cell death with the duration of treatment by MR relaxometry in an animal
model of squamous cell carcinoma of skin. Our MR data correlated with the
findings of histology and biochemical parameters i.e proliferation index and
apoptotic index. Results indicate that MR relaxometry measurements are useful
to monitor cell death in response that could help selection of proper
therapeutic regimen, dose, or duration of drug.