Ana
Isabel Garcia1, Ana Milinkovic2, Iaki Perez3,
Xavier Tomas, Sergi Vidal-Sicart4, Carles Falcon5,
Jaume Pomes, Montserrat Del Amo, Josep Mallolas2
1Radiology, Hospital Clinic,
1H-MR
spectroscopy was performed to assess intramyocelullar lipids (IMCL) in a
group of HIV-patients with lipodystrophy syndrome receiving stable
antiretroviral therapy and their changes 6 months after switching the
treatment. HIV-patients at baseline revealed higher IMCL than controls,
although no significant. Statistical analysis revealed a significant reversal
of peripheral lipoatrophy with decreased of the lean mass after switching the
treatment, and it was related with IMCL decreased, although no significant. A
probable migration of lipid content from intramyocellular to periphery can
explain partially the peripheral fat gain and loss of peripheral lean mass,
although other factors may participate.