Heather Ting Ma1,2, Jing Yuan1,
David K. Yeung1, Yi-Xiang Wang1, James Francis Griffith1
1Department of Diagnostic Radiology and
Organ Imaging, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 2Electronic
and Information Engineering Department, Harbin Institute of Technology
Shenzhen Graduate Shool, Shenzhen, China
Varied
bone marrow perfusion function in some bone diseases has been identified by
dynamic contrast enhancement (DCE) MRI. This pilot study explored a
non-invasive and quantitative method, combining kinetic model and arterial
spine labeling (ASL) technique, to study bone marrow perfusion at lumbar
spine. A turbo field echo (TFE) acquisition with STAR labeling (STAR-TFE) was
developed for better imaging compared to STAR-EPI. A kinetic model was
applied on the ASL signal to provide a quantitative measure of perfusion
function. The result shows that ASL combined with kinetic modeling is
promising for quantitative study the perfusion in bone marrow.