Francesca C. Norris1,2, Jon O. Cleary1,3,
Marc Modat4, Anthony N. Price1, Karen McCue5,
Sarah Beddow5, Peter J. Scambler5, Sebastien Ourselin4,
Mark F. Lythgoe1
1Centre for Advanced Biomedical
Imaging, Department of Medicine and UCL Institute of Child Health, University
College London, London, United Kingdom; 2Centre for Mathematics
and Physics in the Life Sciences and EXperimental Biology (CoMPLEX),
University College London, London, United Kingdom; 3Department of
Medical Physics and Bioengineering, University College London, London,
England, United Kingdom; 4Centre for Medical Image Computing,
University College London, London, United Kingdom; 5Molecular
Medicine Unit, UCL Institute of Child Health, University College London,
London, United Kingdom
The
increasing use of genetically modified mice has highlighted the need for
effective phenotyping methods. Propagation-based morphometry (PBM) is an
emerging technique enabling non-invasive and rapid acquisition of volumetric
data using an average population atlas for morphometric analysis. Thus, PBM
shows promise for combining high-throughput MR imaging of late-gestation
embryos with high-throughput analysis. We present the first study to assess
and validate the accuracy of volumes generated via PBM in an ex vivo mouse
embryo atlas comprising three different groups. Preliminary results show
promise towards the broad applicability of this technique for phenotyping
mutant mouse models.