Timo
Liimatainen1, Olli Grhn2
1Department of Biotechnology and
Molecular Medicine, University of Kuopio, Kuopio, Finland; 2Department
of Neurobiology, University of Kuopio, Kuopio, Finland
A
pulse sequence based on gradient echo design was modified to include four
hyperbolic secant pulses, following by a signal acquisition. This was
repeated four times to obtain a T1ρ
weighted signal intensity curve with incrementally increasing spin-lock time
for single phase encoding step. T1ρ
relaxation times were compared between developed method and spin echo readout
with a T1ρ
preparation pulse train in mice brains. Similar T1ρ values were obtained with both methods. The
developed method allows acquisition of several incremented spin-lock times
within one repetition time enabling faster quantization of T1ρ and/or decreased
specific absorption rates.