Colin Morehouse Carpenter1, Shudong Jiang2,
Brian William Pogue2, Keith David Paulsen2
1Radiation Oncology, Stanford
University School of Medicine, Stanford, CA, United States; 2Thayer
School of Engineering at Dartmouth, Hanover, NH, United States
IDEAL
water/fat separation was used to improve hemoglobin quantification of
MR-guided optical imaging. This
technique is shown to reduce the cross-talk between oxyhemoglobin and water,
caused by the spectral similarity of these tissue constituents in the
near-infrared. It is demonstrated in
gelatin phantoms that this approach reduces error in oxyhemoglobin by 70% on
average for several cases. This finding has significant benefit for optical
breast imaging, as the improved quantification provided by the MR water
image can be leveraged to reduce the
number of wavelengths in the optical data acquisition and thus increase
temporal resolution.