1Radiation Medicine Program, Princess
Margaret Hospital, Toronto, Ontario, Canada; 2Sunnybrook Research
Institute, Toronto, Ontario, Canada; 3Medical Imaging, University
Health Network, Toronto, Ontario, Canada; 4Medical Imaging,
University of Toronto
A
magnetization-prepared spiral imaging technique, termed T2prep, was adapted
for robust time-efficient clinical prostate evaluation, and piloted in two
prostate cancer cohorts. The patient
groups presented with: (A) no prior history of external beam radiation; and
(B) biochemical failure after radiotherapy.
Cohorts were scanned (A) without and (B) with an endo-rectal coil in
tandem with a torso phased-array, respectively. Prostate zonal and tumor T2 values
supported known trends. For each
cohort, an SNR analysis was performed to identify minimum region volumes for thermal-noise
insensitive measurements, and to guide protocol design for future voxel-based
anlaysis.