Improving Suspicious Breast Lesion Characterization Using Lesion Fractional Volume Washout Kinetic Analysis

Jie Huang¹, Lori Hoisington¹, Sarah Schafer¹, Xiaopeng Zong¹, Kevin Berger¹

This study investigated using lesion fractional volume washout (WO) kinetic analysis for improving the characterization of suspicious contrast-enhancing breast lesions. The WO volume fraction was found to be significantly different between the biopsy-proven benign and malignant lesions of all the suspicious breast lesions with BI-RADS assessment of 4 or 5. It showed a potential to improve the positive predictive value of the biopsies by an improvement rate of 86.8%, and consequently would yield a 72.2% reduction rate to the total number of unnecessary biopsies.