Chenguang Zhao1, Patrick Bolan2,
Melanie Royce3, Anne Marie Wallace4,
1Department of Neurology, University of
New Mexico, Albuquerque, NM, United States; 2Center of Magnetic
Resonance Research, University of Minnesota; 3Cancer Research &
Treatment Center, Univeristy of New Mexico; 4Department of
Surgery, University of New Mexico; 5Biochemistry and Molecular
Biology, University of New Mexico; 6Department of Radiology,
University of New Mexico; 7Pathology, University of New Mexico
Quantification
of total Choline compounds in breast spectra is challenging due to the
contamination of unsuppressed lipids. In vivo breast spectra in healthy
controls were acquired using proton echo planar spectroscopic imaging.
Localized spectra were fitted across the 4.0-2.0ppm range by LCModel using a
basis-set with singlet resonances for tCho and lipid peaks. LCModel fitting
enables identification of the tCho baseline and quantification of the peak
area by spectral integration. In vivo tCho concentrations were consistent
with literature values. This method is suitable for automatic tCho
quantification of breast spectroscopic imaging data of low quality.