Abstract #2789

Dynamic Contrast-Enhanced Magnetic Resonance Imaging Reveals Differences in Xenografts with Luminal Like and Basal Like Gene Expression Pattern

Else Marie Huuse¹, Siver Andre Moestue¹, Olav Engebrten^2,3, Tone Frost Bathen¹, Ingrid Susann Gribbestad¹

¹Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; ²Department of Tumor Biology, Institute for Cancer Research, Oslo, Norway; ³Oslo University Hospital , Oslo, Norway

Molecular sub-classification of breast cancer based on gene expression pattern represents clinically distinct patient groups with different outcome. Two breast cancer xenograft models reflecting two of these groups: Basal like (ER-, poor prognosis) and luminal like (ER+, better prognosis), were characterized using DCE-MRI. Our results shows a significant higher Ktrans in basal like than in luminal like small tumors, however, this difference disappears for large tumors. Estradiol withdrawal had minor effect on growth and DCE-MRI derived parameters for the basal like tumors. The luminal like tumors ceased to grow and had a significant increase in Ktrans and ve .