Serial Multiparametric MRI in Study Design and Response Evaluation of Radiation and Antiangiogenic Therapy in an Intracranial Murine Glioblastoma Model

Caroline Chung¹, Warren Foltz¹, Petra Wildgoose¹, Kelly Burrell², Patricia Lindsay¹, Andrea Kassner³, David Jaffray¹, Gelareh Zadeh^4,5, Cynthia Menard¹

This study demonstrates feasibility of using multiparametric micro-MRI to overcome the challenges of intracranial mouse tumour models. Baseline T2w images were used to select mice with visible tumours and to stratify mice to treatment arms based on tumour size. Serial multiparametric MRI was used to measure tumour growth and vascular changes on DCE-MRI (iAUC60) with radiation (RT) and/or sunitinib (SU) anti-angiogenic treatment. Early rises in iAUC60 were noted following both RT and SU monotherapy, while the combination of RT and SU resulted in an early significant decrease in iAUC60. These early measured DCE-MRI changes show promise as useful early biomarkers for treatment response.