Abstract #2781

Imaging of Tumor Angiogenesis in a Novel Skin Chamber Using MRI and Optical Imaging

Tobias Buerle¹, Clarissa Gillmann², Reiner Umathum¹, Margareta M. Mller³, Michal Neeman⁴, Wolfhard Semmler², Michael Bock¹

¹Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, Germany; ²Medical Physics in Radiology, German Cancer Research Center , Heidelberg, Germany, Germany; ³Tumor- and Microenvironment, German Cancer Research Center, Heidelberg, Germany, Germany; ⁴Biological Regulations, The Weizmann Institute of Science, Rehovot, Israel

Tumor angiogenesis in animal models is often visualized using optical imaging or MRI. In this work we present a subcutaneous skin chamber for simultaneous optical and MR imaging to study the tumor-induced growth of blood vessels in vivo. The fully MR-compatible chamber features an optical window, and can be combined with a dedicated external loop coil.