Christopher S. Ward1, Sabrina M. Ronen1
1Radiology and Biomedical Imaging,
University of California San Francisco, San Francisco, CA, United States
CTP:choline-phosphate
cytidylyltransferase (CCT) is the enzyme responsible for catalyzing the
addition of CTP to phosphocholine to form CDP-choline, which is generally
accepted to be the rate-limiting reaction in the formation of
phosphatidylcholine. This study introduces a dynamic 31P MR-based
means to measure the kinetics of the cytidylyltransferase-catalyzed reaction.
The results suggest the potential of this technique to quantitatively assess
modulations in CCT activity.