Abstract #2767

Comparison of Fatty Acid and Phosphatidylcholine Levels in Breast and Prostate Cancer Cells and Tumors

Noriko Mori¹, Flonne Wides², Tomoyo Takagi², Kristine Glunde², Zaver M. Bhujwalla²

¹JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, , The Johns Hopkins University School of Medicine, Baltimore, MD, United States; ²JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science,, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Elevated lipogenesis is a characteristic feature of cancer. Fatty acid synthase overexpression has been found in many human cancers. Both tumor cells in culture and solid tumor models are essential tools to study cancer biology. To understand the differences in lipid components between tumor cells in culture and solid tumors, we compared fatty acid and phosphatidylcholine levels with 1H MRS of lipid-soluble cell or tumor extracts derived from prostate and breast cancer cell lines. Significantly different patterns of fatty acid levels between cells in culture and in tumors, demonstrate the importance of the tumor microenvironment in lipid metabolism.