Lucy Elizabeth Kershaw1, Marine Beaumont1,
Hai-Ling Margaret Cheng1,2
1The Research Institute and Diagnostic
Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Department
of Medical Biophysics, The University of Toronto, Toronto, Ontario, Canada
This
study presents a dual-bolus technique to measure the arterial input function
(AIF) for DCE-MRI. A low-dose prebolus
was used to estimate the AIF for a tissue uptake curve measured from a second
high-dose injection. AIFs were
measured in the rabbit aorta using a high temporal resolution TRICKS
acquisition. The scaled prebolus AIF
was shown to match the main bolus AIF closely. Measurement of the AIF in a separate
acquisition allows the tissue of interest to be imaged at high spatial
resolution in a DCE-MRI experiment.