Anna Rydhg1, Matthias J. P. van Osch2,
Markus Nilsson1, Jimmy Ltt3, Freddy Sthlberg1,4,
Ronnie Wirestam1, Linda Knutsson1
1Department of Medical Radiation
Physics, Lund University, Lund, Sweden; 2Department of Radiology,
LUMC, Leiden, Netherlands; 3Department of Image and function,
University Hospital Lund, Lund, Sweden; 4Department of Diagnostic
Radiology, Lund University, Lund, Sweden
Intravoxel
Incoherent Motion (IVIM) is a non-invasive method which has the potential to
quantify perfusion parameters such as
CBV and CBF from signal-versus-b data. Simulations was performed
usinga synthetic voxel consisting of four different compartments (tissue,
CSF, arterial and venous blood ) for comparison of the expected signal curves
at three field strength (1.5, 3 and 7 T). Confirmation of the simulated
results was obtained from in vivo measurements on a volunteer. We conclude that for higher field strengths
the relative contribution from venous blood decreases suggesting that IVIM at
7 T would primarily reflect arterial blood volume.