Steven
H. Baete1,2, Yves De Deene1,2
1Laboratory for Quantitative Nuclear
Magnetic Resonance in Medicine and Biology, ECNURAD, Ghent University, Ghent,
Belgium; 2MEDISIP-IBBT, Ghent University, Ghent, Belgium
Tumor
hypoxia is well known to reduce cancer treatment efficacy. Fluor-19 MRI
oximetry can be used to map oxygen concentrations in hypoxic tissue. In this
study a reproducible phantom which mimics oxygen consuming tissue is used for
quantitative dynamic fluor-19 MRI oximetry. The phantom consists of a
hemodialysis filter of which the outer compartment is filled with a gelatin
matrix containing viable yeast cells and perfluorocarbon vesicles which
simulate the absorption of perfluorocarbons from intravenous emulsions in
tissue. The phantom can be used for hypoxia simulations and for validating
computational biophysical models of hypoxia, as measured with fluor-19 MRI
oximetry.