Abstract #2743

In Vitro Validation of Permeability-Surface Area Product Derived by Distributed Parameter Model with DCE-MRI

Septian Hartono^1,2, Choon Hua Thng¹, Tong San Koh², Puor Sherng Lee¹, Fang Keang Lim¹, Theng Boon Lee¹, Helmut Rumpel³, Quan Sing Ng¹

¹National Cancer Centre Singapore, Singapore, Singapore; ²Nanyang Technological University, Singapore, Singapore; ³Singapore General Hospital, Singapore

Hollow Fiber Bioreactors (HFBs), typically used for cell culture, mimicks well the human capillary system and thus is ideal to be used to validate the microcirculatory parameters obtained by tracer kinetic modeling. The aim of this study is to validate the permeability-surface area product (PS) obtained by tracer kinetic models with DCE-MRI in a HFB. Linear relationship was found between PS derived from the tracer kinetic models and pore size area of the HFBs.