Ian Tagge1, Ryan A. Priest2,
Tomasz M. Beer3,4, Mark G. Garzotto5,6, William J.
Woodward1, Wei Huang1, Charles S. Springer, Jr.
1,4, Xin Li1
1Advanced Imaging Research Center,
Oregon Health & Science University, Portland, OR, United States; 2Radiology,
Oregon Health & Science University, Portland, OR, United States; 3Hematology/Oncology,
Oregon Health & Science University, Portland, OR, United States; 4Knight
Cancer Institute, Oregon Health & Science University, Portland, OR,
United States; 5Urology, Oregon Health & Science University,
Portland, OR, United States; 6Portland VA Medical Center,
Portland, OR, United States
Dynamic-contrast-enhanced
magnetic resonance imaging (DCE-MRI) has shown promise in diagnostic
medicine, particularly as applied to breast cancer screening. Pharmacokinetic
parameter determination relies on arterial input function (AIF) validity.
However, reliable AIFs are not easily obtained and often cannot be. Thus, it
is often necessary to rely on an averaged, population AIF. The latter is also
desired for data post processing simplification. Here, the standard model
(SM) and first generation shutter-speed model (SSM) are used to assess the
impact of a generic AIF on the pharmacokinetic parameter Ktrans (volume
contrast reagent (CR) transfer constant) estimation in human prostate
studies.