Abstract #2709

Reference Region Based Modeling in DCE-MRI Allows Reliable Therapy Response Monitoring Despite Drug Induced Systemic Changes in a Rat Liver Tumor Model

Andreas Steingoetter^1,2, Jonas Svensson³, Yvonne Kosanke¹, Ernst Rummeny¹, Rickmer Braren¹

¹Institute of Radiology, Klinikum rechts der Isar der TU Mnchen, Munich, Germany; ²Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; ³Department of Medical Radiation Physics, Malmo University Hospital, Lund University, Malmo, Sweden

A limitation in DCE-MRI is the difficulty of simultaneous measurement of arterial input function and CA concentration in tumor tissue. In this study, two anaesthesia protocols, resulting in a ~ 30% change in heart rate, were used to simulate systemic changes in AIF to analyze the robustness of popAIF vs RR modeling in an orthotopic HCC rat tumor model. Different anaethesisa protocols resulted in a significant systematic offset for popAIF based ktrans and ve modeling compared to RR. This study highlights the robustness and feasibility of the reference region approach.