Abstract #2707

The Effects of SDF-CXCR4 Signaling on Tumor Growth: The Involvement of Neural Progenitor Cells

Nai-Wei Yao¹, Chiao-Chi V. Chen¹, Chen Chang¹

¹Functional and Micro-magnetic Resonance Imaging Center, Institution of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

Neural progenitor cells (NPCs) and glioma cells share many common features, including the expression of several cellular markers (such as nestin and CD133), a robust proliferative potential, and pluripotency. The present study demonstrates that tumors exhibited rapid growth following NPCs transplantation while the migration was promoted by the signaling of the stromal cellVderived factor-1 (SDF-1) / CXC chemokine receptor 4 (CXCR4) axis. The finding identified a role of NPCs in tumor expansion.