Abstract #2705

Theranostic Effect of Serial MEMRI on the HESC Induced Teratoma

Jaehoon Chung¹, Rajesh Dash¹, Kehkooi Kee², Joelle Barral³, Irving Weissmann⁴, Dwight Nishimura³, Robert Robbins⁵, Renee Reijo Pera², Phillip C. Yang¹

¹Cardiovascular medicine, Stanford University, Stanford, CA, United States; ²Stem cell biology and regenerative medicine, Stanford University, Stanford, CA, United States; ³Electrical engineering, Stanford University, Stanford, CA, United States; ⁴Pathology, Stanford University, Stanford, CA, United States; ⁵Cardiothoracic surgery, Stanford University, Stanford, CA, United States

Systemic administration of MnCl2 enabled simultaneous monitoring and selective elimination of hESC induced teratoma cells by higher intracellular accumulation of Mn2+. This is the first study to demonstrate MEMRI has a theranostic effect in both detecting and eliminating early teratoma formation.