Abstract #2700

Resistance and Sensitivity to Docetaxel Treatment of Breast Cancer Tissue in Mice Assessed by Analysis of Choline Compounds with HRMAS NMR Spectroscopy

Jack van Asten^1,2, Tone F. Bathen³, Tessa Buckle⁴, Chantal Beekman⁴, Ingrid Gribbestad³, Fijs van Leeuwen⁴, Arend Heerschap¹

¹Radiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; ²Biophysical Chemistry, Radboud University Nijmegen, Nijmegen, Netherlands; ³Dept. of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; ⁴Radiology and Nuclear Medicine, Division of Diagnostic Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital

Breast cancers may be resistant to docetaxel treatment. We investigated the metabolic profile of breast cancer tissue in mouse strains resistant and sensitive to treatment by docetaxel. A typical choline compound profile was found to be predictive for treatment efficiency.