Francois Lazeyras1,2, Leo Buhler3,
Antonio Nastasi3, Raphael Ruttimann3, Philippe Morel3,
Jean-Bernard Buchs3
1Service of Radiology, University of
Geneva and University Hospital of Geneva, Geneva, Switzerland; 2Center
for Biomedical Imaging (CIBM), Lausanne and Geneva, Switzerland; 3Visceral
and Transplantation Service, University of Geneva and University Hospital of
Geneva, Geneva, Switzerland
In
this study, we compare 2 cold storage conditions for transplantation using
31P CSI: Oxygenated pulsatile perfusion (O2+HPP) performed immediately after
kidney harvesting vs. simple cold storage (CSS). We found that ATP did not
fully recovered after 8 hours of CSS, and PME/Pi time constant was similar in
both conditions (~0.05 h-1). Assessment of PME and ATP kinetics are important
in the context of organ evaluation before transplantation as they may be
considered as markers of kidneys viability.