Abstract #2677

Non-Invasive Investigation of Diabetic Kidney Disease by Magnetic Resonance Imaging

Peter Edward Thelwall¹, Roy Taylor¹, Sally M. Marshall²

¹Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom; ²Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

We have applied MR imaging methods to diabetic kidney disease by investigating the differences in kidney structure, blood flow and oxygenation between volunteers with Type 1 diabetes with and without diabetic nephropathy, and in non-diabetic control subjects. We hypothesised that early changes in kidney structure and function caused by diabetic nephropathy could be identified by altered renal structure, blood flow, and changes in oxygenation on water loading. Differences in renal artery flux were observed between volunteer groups.