Susan Moyher Noworolski1,2, Phyllis Tien3,4,
Michelle Nystrom1, Suchandrima Banerjee5, Aliya Qayyum1
1Radiology and Biomedical Imaging,
University of California, San Francisco, CA, United States; 2The
Graduate Group in Bioengineering, University of California, San Francisco and
Berkeley, CA, United States; 3Medicine, University of California,
San Francisco, CA, United States; 4Medicine, Veteran Affairs
Medical Center, San Francisco, CA, United States; 5MR Applied
Science Lab, GE Healthcare, Menlo Park, CA, United States
The
impact of a perfusion regime, low b-value ADC, and a tissue regime, high
b-value ADC were evaluated in comparison to a conventional ADC in three
groups of subjects: HIV/HCV (hepatitis C) coinfection, HIV-monoinfection, and
without infection. Liver ADC was measured using b values of 0 and 150 (ADClow),
150 and 600 (ADChigh) and 0 and 600 (ADCconv) in one
breathhold sequence. ADClow and ADChigh provided unique
information. HIV tended to have the highest ADC levels and was significantly
higher than HIV/HCV for ADClow and ADCconv. HIV status
may thus be an important consideration in interpretation of liver ADC.