Annie M.
Tang1, Kelvin K. Wong1, Kathleen Wyne2,3,
Dikoma C. Shungu4, Willa Hsueh2,5, Stephen T. Wong1
1Center for Bioengineering and
Informatics and Department of Radiology, The Methodist Hospital Research
Institute, Weill Cornell Medical College, Houston, TX, United States; 2Diabetes
Research Center, The Methodist Hospital Research Institute, Houston, TX,
United States; 3Division of Diabetes, Obesity & Lipids, The
Methodist Hospital, Weill Cornell Medical College, Houston, TX, United
States; 4Department of Radiology, Weill Cornell Medical College,
Cornell University, New York, NY, United States; 5Division of
Diabetes, Obesity & Lipids , The Methodist Hospital, Weill Cornell
Medical College, Houston, TX, United States
1H-MRS
is used for quantifying liver fat content
in patients with NAFLD. T2 corrections of hepatic fat/water are
usually done using T2 values obtained in literature. However, these T2 values of depends a lot on the
concentration of iron in the liver. In patients with NAFLD, different degree
of iron concentration was observed depending on the patient sex and diabetes
status. We are conducting an ongoing pilot trial to study the hepatic fat
content in obese patients before and during diet/weight management. The hepatic water and fat T2 relaxation
values were measured and its effects in hepatic fat content measurements were
explored.