Abstract #2605

Fast 3D Dynamic Contrast-Enhanced MRI Pre- And Post-Secretin for Evaluating the Severity of Chronic Pancreatitis

Patrick Hawkins¹, Numan C. Balci², Sharon C. Forrest³, Frank Burton⁴, Samer Alkaade⁴, Thomas Perkins⁵, William H. Perman¹

¹Radiology, Saint Louis University School of Medicine, St. Louis, MO, United States; ²Radiology, Saint Louis University, St. Louis, MO, United States; ³Department of Radiology, Saint Louis University Hospital, St. Louis, MO, United States; ⁴Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, United States; ⁵Philips Healthcare, Cleveland, OH, United States

Currently, secretin stimulation is utilized in MRCP Cambridge classification of chronic pancreatitis. Our study intends to correlate pre- and post-secretin pancreas perfusion with a more precise classification of chronic pancreatitis. Fast 3D dynamic contrast-enhanced MR perfusion scans were performed on 12 subjects with suspected chronic pancreatitis using a 3D T1 weighted turbo field echo pulse sequence. Comparison of the perfusion values between Cambridge type 3 and type 1 subjects, with normal exocrine function demonstrate a significant difference in regional and average arterial to tissue wash-in and wash-out rates. Conclusion: Contrast-enhanced MRI shows promise as a staging technique for chronic pancreatitis.