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Abstract #2553

Signal Dynamics During Dissolved-Phase Hyperpolarized 129Xe Radial MR Imaging of Human Lungs

Zackary I. Cleveland1,2, Gary P. Cofer1,2, Gregory Metz3, Denise Beaver3, John Nouls1,2, Sivaram Kaushik1,2, Monica Kraft3, Jan Wolber4, Kevin T. Kelly5, H Page McAdams2, Bastiaan Driehuys1,2

1Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States; 2Radiology, Duke University Medical Center, Durham, NC, United States; 3Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, United States; 4GE Healthcare, Amersham, United Kingdom; 5Radiation Oncology, Duke University Medical Center, Durham, NC, United States


It is now possible to directly image HP 129Xe dissolved in pulmonary gas exchange tissues of humans. Dissolved image intensity is dominated by relaxation, RF attenuation, and diffusive replenishment of dissolved 129Xe magnetization, which are influenced by pulmonary structure and physiology. Here, we develop a closed-form mathematical model of dissolved 129Xe magnetization dynamics during 3D radial imaging. Model predictions agree well with observations and can be used in image optimization. Because radial images acquire k-zero in each view, the model also allows dynamic information to be extracted from raw image data and may provide insights into global lung physiology.