Chengbo Wang1, John P. Mugler, III1,2,
Eduard E. de Lange1, Kai Ruppert1, William F. Hersman3,4,
Isabel M. Dregely3, Iulian Ruset, 3,4, Stephen Ketel4,
Talissa A. Altes1
1Radiology, University of Virginia,
Charlottesville, VA, United States; 2Biomedical Engineering,
University of Virginia, Charlottesville, VA, United States; 3Physics,
University of New Hampshire, Durham, NH, United States; 4Xemed
LLC, Durham, NH, United States
Regional
ADC maps of hyperpolarized 129Xe in human lungs measured over both short and
long time scales and with identical spatial registration during a single
breath hold were acquired in 5 human subjects. Measured 129Xe ADC values were about 10% of
the corresponding previously reported 3He ADC values for both time scales,
similar to the expected difference of 16% due to the differences in
diffusivity of the gases. The current
SNR of 129Xe MRI is sufficient for diffusion MRI, and 129Xe diffusion MRI has
been performed in healthy subjects and subjects with lung disease.