Line R. Jensen1, Benjamin Garzon1,
Mariann G. Heldahl1, Tone F. Bathen1, Pl E. Goa1,
Steinar Lundgren1,2, Ingrid S. Gribbestad1
1Department of Circulation and Medical
Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Department
of Oncology, St. Olavs University Hospital, Trondheim, Norway
The
purpose of this study was to use MRI for early evaluation of treatment
effects in breast cancer patients undergoing neoadjuvant chemotherapy, and to
identify MRI parameters at 3T that correlate to treatment response. In
addition, the reproducibility of diffusion weighted MRI was assessed. The ADC
values from two baseline examinations showed good reproducibility, with ICC
of 0.84. The best predictors of pathologic treatment response were the change
in the longest diameter measured on MRI, followed by mean and skewness of
ADC, and Ktrans entropy.